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MDS FISH Panel (FISH[del(5q), del(7q), del(20q)]) Test

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MDS FISH Panel (FISH[del(5q), del(7q), del(20q)]) Test

Short Name: MDS FISH Panel

Also known as: MDS FISH Panel, FISH del(5q) del(7q) del(20q), Myelodysplastic Syndrome FISH Panel

MDS FISH Panel (FISH[del(5q), del(7q), del(20q)]) Test test available at DNA Labs India for ₹10,500. Uses Fluorescence In Situ Hybridization (FISH) on Bone marrow / Peripheral blood samples. Results in Reports are available within 5-7 days after sample collection.. Free home collection in 300+ cities across India.

FISH (Fluorescence In Situ Hybridization)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the MDS FISH Panel is to detect specific chromosomal deletions (del(5q), del(7q), del(20q)) in patients suspected of having myelodysplastic syndrome. These genetic abnormalities help confirm the diagnosis, determine the subtype of MDS, assess prognosis, and guide treatment options. For example, del(5q) is associated with a favorable prognosis and response to lenalidomide, while del(7q) or complex karyotypes indicate higher risk. The test is also useful in monitoring disease progression and detecting minimal residual disease after therapy.

Test Code
6130
CPT Code
88271, 88275, 88291
ICD Code
D46.9
Price
₹10,500
Sample Type
Bone marrow / Peripheral blood
Result Time
Reports are available within 5-7 days after sample collection.
Fasting Required
No
Method
Fluorescence In Situ Hybridization (FISH)
Step 1

Sample Collection

No fasting required. Inform your doctor about any medications or recent transfusions. A doctor's prescription is mandatory for this test.

Method: Venipuncture / Bone marrow aspiration

Step 2

Laboratory Analysis

Peripheral blood sample will be collected by venipuncture. For bone marrow, a small sample will be aspirated from the hip bone under local anesthesia.

Step 3

Report Delivery

You may resume normal activities. If bone marrow biopsy was performed, keep the site clean and dry. Apply pressure if bleeding occurs.

Timeline: Reports are available within 5-7 days after sample collection.

Patient Instructions

1
Before the Test:No special preparation required. Ensure you have a doctor's prescription.
2
During the Test:Blood sample collection is quick and minimally invasive. Bone marrow aspiration may cause brief discomfort.
3
After the Test:You can resume normal activities. For bone marrow, avoid strenuous activity for 24 hours.

About This Test

Who Should Get This Test

The purpose of the MDS FISH Panel is to detect specific chromosomal deletions (del(5q), del(7q), del(20q)) in patients suspected of having myelodysplastic syndrome. These genetic abnormalities help confirm the diagnosis, determine the subtype of MDS, assess prognosis, and guide treatment options. For example, del(5q) is associated with a favorable prognosis and response to lenalidomide, while del(7q) or complex karyotypes indicate higher risk. The test is also useful in monitoring disease progression and detecting minimal residual disease after therapy.

How to Prepare

  • Use Sodium Heparin Vacutainer for blood sample
  • Transport immediately to the laboratory at room temperature (cool pack if delay)
  • Do not freeze the sample
  • Label the sample with patient ID and date

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"The MDS FISH panel is essential for identifying specific chromosomal deletions that guide prognosis and treatment decisions in myelodysplastic syndrome. Early detection can significantly improve patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBone marrow / Peripheral blood
Sample Volume2 ml
ContainerSodium Heparin Vacutainer
Collection MethodVenipuncture / Bone marrow aspiration

Sample Stability

Peripheral blood: 24-48 hours at room temperature
Bone marrow: 24 hours at room temperature
Refrigerated (2-8°C): up to 72 hours
Sample Rejection Criteria:
  • Clotted sample
  • Hemolyzed sample
  • Incorrect anticoagulant
  • Sample older than 72 hours
  • Unlabeled or mislabeled sample

Understanding Your Results

The MDS FISH Panel results are reported as positive or negative for each deletion. A positive result indicates the presence of the specific chromosomal deletion, which may support the diagnosis of MDS and provide prognostic information. Negative results do not exclude MDS, as other genetic abnormalities may be present.
📊

del(5q) positive

Indicates 5q- syndrome, often associated with anemia, normal or elevated platelet count, and favorable response to lenalidomide.

📊

del(7q) positive

Associated with poor prognosis, higher risk of transformation to AML, and may require aggressive therapy.

📊

del(20q) positive

Variable prognosis; may be seen in MDS and other myeloid disorders. Clinical correlation needed.

📊

All negative

No deletion detected in the tested regions. MDS cannot be excluded; further genetic testing may be warranted.

⚠️ When to Consult a Doctor:

Consult your doctor if you experience persistent fatigue, weakness, frequent infections, easy bruising, or bleeding. Early diagnosis of MDS is crucial for timely management.

Limitations

  • ⚠FISH only detects specific deletions; other chromosomal abnormalities may be missed
  • ⚠Low-level mosaicism may not be detected
  • ⚠Results should be interpreted in conjunction with bone marrow morphology and clinical findings
  • ⚠Not a standalone diagnostic test for MDS

Risks & Considerations

  • ●Minimal risk of bleeding or infection at the puncture site
  • ●Bone marrow aspiration may cause temporary pain or soreness
  • ●Rare risk of nerve damage (very low)

Interfering Factors

  • ●Recent blood transfusion may dilute abnormal cells
  • ●Inadequate sample volume or poor quality DNA
  • ●Clotting of sample due to improper handling
  • ●Delayed transport leading to cell degradation
  • ●Concurrent chemotherapy may affect FISH results

Compare With Similar Tests

TestMDS FISH Panel (FISH[del(5q), del(7q), del(20q)])Conventional Cytogenetics (Karyotyping)MDS FISH Panel
ComparisonMDS FISH Panel (FISH[del(5q), del(7q), del(20q)])

Frequently Asked Questions

What is the MDS FISH Panel?
It is a genetic test that detects specific chromosomal deletions (del(5q), del(7q), del(20q)) associated with Myelodysplastic Syndrome using FISH technology.
Why is this test important for MDS?
It helps confirm diagnosis, determine prognosis, and guide treatment decisions based on specific genetic abnormalities.
What sample is required?
Bone marrow aspirate or peripheral blood (2 ml in Sodium Heparin vacutainer).
Do I need to fast before the test?
No, fasting is not required.
How long does it take to get results?
Results are typically available within 5-7 days.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in many cities.
What is the cost of the test?
The cost is INR 10,500, which is a discounted price.
Can this test be done without a doctor's prescription?
No, a doctor's prescription is mandatory, except for surgery or pregnancy cases.
What does a positive del(5q) result mean?
It indicates the presence of 5q deletion, often associated with a favorable prognosis and potential response to lenalidomide.
Are there any risks involved?
Risks are minimal, mainly related to blood draw or bone marrow aspiration, such as bleeding or infection.
Is the test covered by insurance?
Coverage varies; please check with your insurance provider.
Where is the test available?
The test is available across India, including major cities like Mumbai, Delhi, Bangalore, and Hyderabad.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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