MET Amplification (NSCLC) Test
Also known as: MET Gene Amplification Test, MET FISH Test, MET Amplification FISH Assay
MET Amplification (NSCLC) Test test available at DNA Labs India for ₹9,000. Uses FISH (Fluorescence In Situ Hybridization) on Tumor tissue samples. Results in 7-8 days from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of MET Amplification testing is to identify genetic mutations in NSCLC patients that can guide targeted therapy selection, monitor treatment response, and support personalized medicine approaches for improved patient outcomes.
- Test Code
- 3086
- Price
- ₹9,000
- Sample Type
- Tumor tissue
- Result Time
- 7-8 days from sample receipt
- Fasting Required
- No
- Method
- FISH (Fluorescence In Situ Hybridization)
Sample Collection
Ensure a doctor's prescription is available. Inform the lab of any medications or prior treatments. No specific fasting required for tissue biopsy.
Method: Tissue biopsy
Laboratory Analysis
Tissue biopsy is performed by a healthcare professional, typically via surgical resection or needle biopsy. The sample is preserved in paraffin for analysis.
Report Delivery
Apply pressure to biopsy site to prevent bleeding. Follow post-procedure care instructions from the healthcare provider. Sample is sent to the lab for processing.
Timeline: 7-8 days from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The purpose of MET Amplification testing is to identify genetic mutations in NSCLC patients that can guide targeted therapy selection, monitor treatment response, and support personalized medicine approaches for improved patient outcomes.
How to Prepare
- Obtain a valid doctor's prescription for the test
- Use sterile equipment for tissue collection
- Preserve sample in appropriate fixative (e.g., formalin) for paraffin embedding
- Label sample correctly with patient details
- Transport sample at ambient temperature to the lab
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"MET Amplification testing is crucial for identifying targeted therapy options in NSCLC patients, enabling personalized treatment plans that can improve outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample with insufficient tumor content
- Improperly labeled or unlabeled samples
- Samples with extensive necrosis or degradation
- Missing or invalid doctor's prescription
Understanding Your Results
Consult an oncologist immediately upon receiving positive results for treatment planning. For negative or equivocal results, discuss further testing or therapy options with your healthcare provider.
Limitations
- ⚠False negatives may occur if amplification is focal or heterogeneous
- ⚠False positives due to technical artifacts or polysomy
- ⚠Test only detects amplification, not other MET alterations like mutations
- ⚠Results should be interpreted in conjunction with clinical and histopathological data
Risks & Considerations
- ●Biopsy-related risks: bleeding, infection, or discomfort at the collection site
- ●Minimal risk from the FISH test itself, as it is a laboratory procedure
Interfering Factors
- ●Poor tissue sample quality or insufficient tumor cells
- ●Improper fixation or embedding of tissue blocks
- ●Technical errors in FISH procedure or analysis
- ●Presence of necrotic or degraded tissue
Compare With Similar Tests
| Test | MET Amplification (NSCLC) | EGFR Mutation Test | ALK Rearrangement Test | ROS1 Rearrangement Test | PD-L1 Expression Test |
|---|---|---|---|---|---|
| Comparison | MET Amplification (NSCLC) | Detects EGFR mutations; often performed alongside MET testing for comprehensive profiling. | Identifies ALK gene fusions; complementary to MET testing in NSCLC diagnosis. | Screens for ROS1 alterations; used in parallel with MET for targeted therapy selection. | Assesses PD-L1 levels for immunotherapy eligibility; different mechanism from MET testing. |
Frequently Asked Questions
What is MET Amplification in NSCLC?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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