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DNA Labs India

Microarray 60K (AF/CVS) + Karyotyping + FISH chromosome 21 Test

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Microarray 60K (AF/CVS) + Karyotyping + FISH chromosome 21 Test

Short Name: Microarray 60K + Karyotyping + FISH Chr21

Also known as: Chromosomal Microarray Analysis, Karyotype Test, FISH for Chromosome 21, Prenatal Genetic Screening

Microarray 60K (AF/CVS) + Karyotyping + FISH chromosome 21 Test test available at DNA Labs India for ₹25,500. Uses Microarray Analysis [Agilent], Cell Culture, Fluorescence In Situ Hybridization (FISH) on Amniotic fluid/ Chorionic villi samples. Results in 7-9 days. Free home collection in 300+ cities across India.

Genetic Diagnostic TestPrenatal🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose chromosomal abnormalities such as Down syndrome (trisomy 21), other aneuploidies, copy number variations, and loss of heterozygosity, aiding in prenatal care and genetic counseling.

Test Code
3085
Price
₹25,500
Sample Type
Amniotic fluid/ Chorionic villi
Result Time
7-9 days
Fasting Required
No
Method
Microarray Analysis [Agilent], Cell Culture, Fluorescence In Situ Hybridization (FISH)
Step 1

Sample Collection

Consult with a healthcare provider or genetic counselor. No specific preparation is required, but follow medical advice for amniocentesis or CVS procedures.

Method: Amniocentesis or Chorionic Villus Sampling (CVS)

Step 2

Laboratory Analysis

Sample is collected via amniocentesis (amniotic fluid) or chorionic villus sampling (CVS) under ultrasound guidance by a trained professional.

Step 3

Report Delivery

Rest and monitor for any complications such as cramping or bleeding. Contact healthcare provider if severe symptoms occur.

Timeline: 7-9 days

Patient Instructions

1
Before the Test:Consult with a healthcare provider to discuss the need for the test. No fasting required.
2
During the Test:Sample collection procedure performed by a specialist, typically taking 15-30 minutes.
3
After the Test:Resume normal activities after rest. Monitor for any adverse effects.

About This Test

Who Should Get This Test

To diagnose chromosomal abnormalities such as Down syndrome (trisomy 21), other aneuploidies, copy number variations, and loss of heterozygosity, aiding in prenatal care and genetic counseling.

How to Prepare

  • Use sterile container or sterile normal saline container
  • Transport sample with cool pack to maintain stability
  • Label container with patient details
  • Ensure timely delivery to the lab

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This comprehensive test is crucial for early detection of chromosomal abnormalities in prenatal care, aiding in informed decision-making and management."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeAmniotic fluid/ Chorionic villi
ContainerSterile Container/ Sterile Normal Saline Container
Collection MethodAmniocentesis or Chorionic Villus Sampling (CVS)

Sample Stability

Sample should be processed within 24 hours of collection
Store at 2-8°C if delayed
Sample Rejection Criteria:
  • Hemolyzed or contaminated sample
  • Unlabeled or improperly labeled container
  • Insufficient sample volume

Understanding Your Results

Results indicate the presence or absence of chromosomal abnormalities. Abnormal findings may require further genetic counseling and clinical evaluation.
📊

Normal

No chromosomal abnormalities detected. Continue routine prenatal care.

📊

Abnormal - Trisomy 21

Presence of three copies of chromosome 21, indicating Down syndrome. Consult genetic counselor for management options.

📊

Abnormal - Other CNVs

Detection of pathogenic copy number variations. Further evaluation and counseling recommended.

📊

Abnormal - LOH

Loss of heterozygosity detected, which may indicate uniparental disomy or other conditions. Requires specialist review.

⚠️ When to Consult a Doctor:

If results are abnormal, or if you experience symptoms like severe pain, fever, or bleeding after sample collection, consult your healthcare provider or genetic counselor immediately.

Limitations

  • ⚠Cannot detect all genetic disorders, such as single-gene mutations
  • ⚠May have false positives or negatives in rare cases
  • ⚠Limited to chromosomal-level abnormalities; does not assess point mutations

Risks & Considerations

  • ●Risk of miscarriage (1-2% for amniocentesis or CVS)
  • ●Infection or bleeding at the collection site
  • ●Cramping or discomfort post-procedure

Interfering Factors

  • ●Contaminated or insufficient sample volume
  • ●Maternal cell contamination in amniotic fluid
  • ●Improper sample storage or transport

Frequently Asked Questions

What is the Microarray 60K (AF/CVS) + Karyotyping + FISH Chromosome 21 test?
It is a comprehensive genetic test that analyzes chromosomes for abnormalities using microarray, karyotyping, and FISH techniques, primarily for prenatal diagnosis.
Why is this test recommended?
It is recommended for individuals with symptoms like developmental delays, recurrent miscarriages, or abnormal ultrasound findings to diagnose chromosomal disorders such as Down syndrome.
How is the sample collected?
The sample is collected via amniocentesis (amniotic fluid) or chorionic villus sampling (CVS) under ultrasound guidance by a healthcare professional.
What is the cost of the test?
The test costs INR 25500, which includes home sample collection and genetic counselor review.
How long does it take to get results?
Results are typically available within 7-9 days after sample collection.
Is home collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across India.
What are the risks of the test?
Risks include a small chance of miscarriage (1-2%), infection, bleeding, or discomfort at the collection site.
How accurate is the test?
The test is highly accurate for detecting chromosomal abnormalities, but no test is 100% foolproof. Results should be interpreted by a genetic counselor.
What should I do if the results are abnormal?
Consult a genetic counselor or healthcare provider to discuss implications, management options, and further testing if needed.
Is the test covered by insurance?
Coverage varies by insurance plan. It is advisable to check with your provider. DNA Labs India offers affordable pricing.
Can this test detect Down syndrome?
Yes, the FISH Chromosome 21 component specifically detects abnormalities related to chromosome 21, including Down syndrome (trisomy 21).
How do I prepare for the test?
No special preparation is required. Follow your healthcare provider's instructions for the collection procedure and ensure a doctor's prescription if needed.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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