MM FISH Panel (FISH[del(11q), del(13q), IgH, del(17p)] Test
Short Name: MM FISH Panel
Also known as: Multiple Myeloma FISH Panel, MM Cytogenetic FISH Panel, Myeloma FISH Test, Plasma Cell Neoplasm FISH Panel
MM FISH Panel (FISH[del(11q), del(13q), IgH, del(17p)] Test test available at DNA Labs India for ₹14,850. Uses Fluorescence In Situ Hybridization (FISH) on Bone Marrow Aspirate / Peripheral Blood samples. Results in 5-7 working days from sample receipt at the laboratory. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The MM FISH Panel is used to detect specific chromosomal abnormalities in plasma cells that are associated with multiple myeloma. Identifying these genetic aberrations helps oncologists determine the prognosis, classify the disease risk category, and select the most appropriate treatment regimen. The panel covers four key markers: del(11q), del(13q), IgH rearrangement, and del(17p), all of which carry clinical significance in risk stratification and therapeutic decision-making.
- Test Code
- 3104
- CPT Code
- 88271
- ICD Code
- C90.0
- Price
- ₹14,850
- Sample Type
- Bone Marrow Aspirate / Peripheral Blood
- Result Time
- 5-7 working days from sample receipt at the laboratory
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No special preparation such as fasting is required. A doctor's prescription is required for this test. Inform the healthcare provider about any ongoing treatments, medications, or recent chemotherapy sessions. Ensure the sample is collected by a trained phlebotomist or hematologist.
Method: Bone Marrow Aspiration / Venipuncture
Laboratory Analysis
For bone marrow aspiration, the procedure is performed under local anesthesia at the posterior iliac crest. For peripheral blood, a standard venipuncture is performed. The sample must be collected in a Sodium Heparin Vacutainer (green top, 2 mL) and gently mixed to prevent clotting.
Report Delivery
The sample must be transported immediately at room temperature (18-25°C) to the laboratory. Do not refrigerate or freeze the sample. Ensure the sample reaches the testing facility within 24 hours of collection for optimal results.
Timeline: 5-7 working days from sample receipt at the laboratory
Patient Instructions
About This Test
Who Should Get This Test
The MM FISH Panel is used to detect specific chromosomal abnormalities in plasma cells that are associated with multiple myeloma. Identifying these genetic aberrations helps oncologists determine the prognosis, classify the disease risk category, and select the most appropriate treatment regimen. The panel covers four key markers: del(11q), del(13q), IgH rearrangement, and del(17p), all of which carry clinical significance in risk stratification and therapeutic decision-making.
How to Prepare
- Collect sample in a Sodium Heparin Vacutainer (green top, 2 mL).
- Gently invert the tube 8-10 times immediately after collection.
- Transport the sample at room temperature (18-25°C) with a cool pack if ambient temperature is high.
- Do not refrigerate or freeze the sample.
- Label the sample correctly with patient details and date/time of collection.
- Ensure the sample reaches the laboratory within 24 hours of collection.
- Include a copy of the doctor's prescription and completed requisition form.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The MM FISH Panel is an essential prognostic tool in the management of multiple myeloma. Detection of high-risk abnormalities such as del(17p) and IgH translocations directly influences treatment stratification. Patients harboring del(17p) have a significantly shorter progression-free survival and may require more aggressive therapeutic approaches, including proteasome inhibitors, immunomodulatory drugs, or consideration for early autologous stem cell transplantation. I recommend this panel for every newly diagnosed myeloma patient as part of the initial workup, and again at relapse to assess clonal evolution."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted sample
- Sample collected in EDTA or other non-heparin anticoagulant
- Sample received after 24 hours of collection
- Insufficient sample volume (less than 1 mL)
- Missing or illegible patient identification
- Sample without accompanying doctor's prescription
Understanding Your Results
No detectable deletion or rearrangement of the tested loci. This is generally associated with standard-risk multiple myeloma. However, absence of these abnormalities does not rule out other genetic changes.
Deletion of 17p (TP53 locus) is detected. This is a high-risk abnormality associated with aggressive disease, poor response to standard therapy, short remission duration, and poor overall survival. Intensified treatment strategies are typically recommended.
Deletion or monosomy of chromosome 13q is detected. This is associated with an adverse prognosis, particularly when co-occurring with other high-risk abnormalities such as t(4;14) or del(17p).
An immunoglobulin heavy chain gene rearrangement is detected, suggesting a translocation involving the 14q32 locus. The specific partner chromosome determines the risk category: t(11;14) is generally standard risk, while t(4;14) and t(14;16) are high risk.
Deletion of 11q is detected, which may involve the ATM gene. This abnormality is associated with intermediate to poor prognosis and may influence treatment intensity.
Detection of two or more abnormalities, particularly del(17p) combined with other markers, indicates a very high-risk disease profile requiring aggressive treatment and close monitoring.
Consult your oncologist or hematologist if you have been diagnosed with multiple myeloma, MGUS, or smoldering myeloma and have not yet undergone FISH testing. Also consult if you experience persistent bone pain, unexplained fatigue, recurrent infections, or unexplained weight loss, as these may be symptoms of plasma cell disorders requiring evaluation.
Limitations
- ⚠FISH detects only the specific chromosomal abnormalities targeted by the probes used; other genetic aberrations may be missed.
- ⚠Results are dependent on the percentage of plasma cells in the sample; low plasma cell infiltration may yield false negatives.
- ⚠This test does not replace comprehensive cytogenetic analysis or next-generation sequencing for complete genomic profiling.
- ⚠Subclonal abnormalities present in a small fraction of cells may not be reliably detected.
- ⚠FISH results should always be interpreted in conjunction with clinical findings, bone marrow morphology, and other laboratory data.
Risks & Considerations
- ●For bone marrow aspiration: mild pain or discomfort at the collection site
- ●Minor bruising or bleeding at the aspiration/venipuncture site
- ●Rare risk of infection at the bone marrow aspiration site
- ●Temporary soreness lasting 1-2 days after bone marrow collection
Interfering Factors
- ●Sample clotting due to improper anticoagulant mixing
- ●Insufficient number of plasma cells in the sample
- ●Delayed sample transport leading to cell degradation
- ●Use of incorrect anticoagulant (EDTA instead of sodium heparin)
- ●Prior chemotherapy may reduce the number of abnormal cells detectable
Compare With Similar Tests
| Test | MM FISH Panel (FISH[del(11q), del(13q), IgH, del(17p)] | Conventional Karyotyping | Next-Generation Sequencing (NGS) for Myeloma | Bone Marrow Biopsy with Immunohistochemistry |
|---|---|---|---|---|
| Comparison | MM FISH Panel (FISH[del(11q), del(13q), IgH, del(17p)] | Conventional karyotyping provides a genome-wide view of chromosomal abnormalities but has lower sensitivity for detecting cryptic aberrations. FISH offers higher sensitivity for specific targeted abnormalities and can detect abnormalities in non-dividing cells. | NGS panels can detect a broader range of mutations and translocations with higher resolution. However, the MM FISH Panel is more widely available, cost-effective, and remains the standard of care for initial cytogenetic evaluation in multiple myeloma. | Bone marrow biopsy evaluates morphology and plasma cell percentage but does not provide specific genetic information. The MM FISH Panel complements biopsy by adding molecular-level prognostic data. |
Frequently Asked Questions
What is the MM FISH Panel test?
Why is the MM FISH Panel important for multiple myeloma patients?
What sample is required for the MM FISH Panel?
Is fasting required before the MM FISH Panel test?
How long does it take to get the MM FISH Panel results?
What does a positive result for del(17p) mean?
Can the MM FISH Panel be done on peripheral blood instead of bone marrow?
What is the cost of the MM FISH Panel at DNA Labs India?
Is the MM FISH Panel covered under insurance or government health schemes?
How is the MM FISH Panel different from conventional karyotyping?
When should the MM FISH Panel be performed?
Does a negative MM FISH Panel result mean I do not have multiple myeloma?
Related Tests
B-Cell Rearrangement Detection Test
₹22,000Acute Lymphoblastic Leukemia (ALL) Cytogenetics Panel Test
₹20,000Epstein-Barr Virus Early RNA (EBER-ISH) In-Situ-Hybridization Test
₹6,000OncoPro NCCN Lung Cancer Panel with PD-L1 Test
₹140,400Acute Myeloid Leukemia (AML) Cytogenetics Panel Test
₹23,000AML ETO t(8;21) Gene Rearrangement PCR Qualitative Test
₹6,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.