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Myeloproliferative Neoplasia with Eosinophilia Test

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Myeloproliferative Neoplasia with Eosinophilia Test

Short Name: MPN with Eosinophilia Test

Also known as: MPN-EOS Test, Eosinophilia MPN Test

Myeloproliferative Neoplasia with Eosinophilia Test test available at DNA Labs India for ₹21,000. Uses Electrical Impedance, Microscopy, Fluorescence In Situ Hybridization (FISH) on Whole blood and bone marrow samples. Results in Reports are available within 7 working days via online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.

Molecular Diagnostic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the Myeloproliferative Neoplasia with Eosinophilia Test is to diagnose myeloproliferative neoplasms associated with eosinophilia by identifying genetic rearrangements in PDGFRA, PDGFRB, and FGFR1 genes. This helps in confirming the disease, guiding therapeutic strategies, and predicting patient outcomes, especially for BCR-ABL1 negative cases.

Test Code
1284
Price
₹21,000
Sample Type
Whole blood and bone marrow
Result Time
Reports are available within 7 working days via online portal, email, or WhatsApp.
Fasting Required
No
Method
Electrical Impedance, Microscopy, Fluorescence In Situ Hybridization (FISH)
Step 1

Sample Collection

Ensure the Chromosome & FISH Analysis Requisition form (Form 17) is duly filled. No fasting is required, but inform the doctor about any medications or health conditions.

Method: Venipuncture and Bone Marrow Aspiration

Step 2

Laboratory Analysis

Blood samples are drawn via venipuncture into specified tubes. Bone marrow samples are collected through aspiration from the hip bone under sterile conditions.

Step 3

Report Delivery

Apply pressure to the collection site to prevent bleeding. Monitor for any signs of infection or excessive pain. Samples are shipped at 18-22°C without freezing.

Timeline: Reports are available within 7 working days via online portal, email, or WhatsApp.

Patient Instructions

1
Before the Test:No special preparation is needed, but ensure the requisition form is completed. Discuss any medications with your doctor.
2
During the Test:The test involves blood collection and bone marrow aspiration, which may cause mild discomfort. Procedures are performed by trained professionals.
3
After the Test:You can resume normal activities. Apply pressure to the collection sites and report any severe pain or bleeding to your doctor.

About This Test

Who Should Get This Test

The purpose of the Myeloproliferative Neoplasia with Eosinophilia Test is to diagnose myeloproliferative neoplasms associated with eosinophilia by identifying genetic rearrangements in PDGFRA, PDGFRB, and FGFR1 genes. This helps in confirming the disease, guiding therapeutic strategies, and predicting patient outcomes, especially for BCR-ABL1 negative cases.

How to Prepare

  • Duly filled Chromosome & FISH Analysis Requisition form (Form 17) is mandatory
  • Collect 3 mL whole blood in Lavender Top (EDTA) tube
  • Collect 2 mL bone marrow in Lavender Top (EDTA) tube
  • Collect 3 mL bone marrow in Green Top (Sodium Heparin) tube
  • Ship samples at room temperature (18-22°C) without freezing

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early detection through genetic testing is crucial for personalized treatment in myeloproliferative neoplasms with eosinophilia, improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood and bone marrow
Sample Volume3 mL whole blood, 2 mL bone marrow in EDTA, 3 mL bone marrow in Sodium Heparin
ContainerLavender Top (EDTA) tube and Green Top (Sodium Heparin) tube
Collection MethodVenipuncture and Bone Marrow Aspiration

Sample Stability

Room Temperature
Refrigerator
Frozen
Sample Rejection Criteria:
  • Incomplete or missing requisition form
  • Improper sample type or volume
  • Samples frozen or stored at incorrect temperature
  • Hemolyzed or clotted samples
  • Delay in shipment beyond stability period

Understanding Your Results

Results from the Myeloproliferative Neoplasia with Eosinophilia Test indicate the presence or absence of genetic rearrangements associated with the disease. Positive results confirm the diagnosis and guide treatment, while negative results may require further evaluation.
📊

Positive for PDGFRA/PDGFRB/FGFR1 rearrangement

Confirms Myeloproliferative Neoplasia with Eosinophilia; targeted therapies may be recommended

📊

Negative for rearrangements

No evidence of these genetic abnormalities; consider other causes of eosinophilia and additional testing

📊

Elevated eosinophil count with normal genetics

May indicate reactive eosinophilia; clinical correlation and follow-up advised

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms such as persistent fever, fatigue, weight loss, shortness of breath, skin rash, joint pain, or enlarged spleen/liver, or if test results are abnormal for further diagnosis and management.

Limitations

  • ⚠May not detect all rare genetic mutations
  • ⚠Requires confirmation with clinical findings
  • ⚠Bone marrow biopsy carries minor procedural risks
  • ⚠Results may vary based on sample quality
  • ⚠Not suitable for screening in asymptomatic individuals without risk factors

Risks & Considerations

  • ●Minor bleeding or bruising at blood collection site
  • ●Infection risk from bone marrow aspiration
  • ●Rare allergic reactions to local anesthesia
  • ●Discomfort during bone marrow procedure

Interfering Factors

  • ●Sample hemolysis or clotting
  • ●Recent chemotherapy or radiation therapy
  • ●Improper sample storage or shipping conditions
  • ●Contamination during collection
  • ●Medications that affect eosinophil levels

Compare With Similar Tests

TestMyeloproliferative Neoplasia with Eosinophilia TestComplete Blood Count (CBC)Bone Marrow BiopsyBCR-ABL1 Test
ComparisonMyeloproliferative Neoplasia with Eosinophilia TestCBC measures eosinophil levels but does not detect genetic rearrangements; this test provides specific genetic diagnosisBone marrow biopsy assesses cell morphology; this test adds molecular analysis for accurate classificationBCR-ABL1 tests for Philadelphia chromosome; this test is for BCR-ABL1 negative cases with eosinophilia

Frequently Asked Questions

What is Myeloproliferative Neoplasia with Eosinophilia?
It is a rare blood disorder where the bone marrow produces excess eosinophils, potentially damaging organs, and involves genetic rearrangements like PDGFRA, PDGFRB, and FGFR1.
Why is this test important?
This test identifies specific genetic abnormalities for accurate diagnosis, treatment planning, and prognosis in BCR-ABL1 negative myeloproliferative neoplasms.
What are the symptoms that indicate the need for this test?
Symptoms include fever, fatigue, weight loss, shortness of breath, skin rash, joint pain, and enlarged spleen or liver.
How is the test performed?
It involves collecting whole blood and bone marrow samples, analyzed using electrical impedance, microscopy, and FISH techniques.
What is the cost of the test?
The test costs INR 21000.0 at DNA Labs India, with free home sample collection available.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
How long does it take to get results?
Results are typically available within 7 working days after sample collection.
What do positive results mean?
Positive results confirm Myeloproliferative Neoplasia with Eosinophilia due to genetic rearrangements, guiding targeted treatments.
Are there any risks associated with the test?
Risks are minimal, including minor bleeding or infection from bone marrow aspiration, but procedures are safe when done by professionals.
Who should take this test?
Individuals with unexplained eosinophilia, symptoms of the disorder, or family history of blood disorders should consider testing.
How do I prepare for the test?
Ensure the requisition form is filled, and inform your doctor about any medications. No fasting is required.
Is the test covered by insurance?
Coverage depends on your insurance plan; check with your provider. DNA Labs India offers it at a discounted price without insurance.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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