Myositis Profile IgG: 11 Antigens Test
Short Name: Myositis Profile IgG
Myositis Profile IgG: 11 Antigens Test test available at DNA Labs India for ₹10,000. Uses Immunoblot on Serum samples. Results in Same day. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Myositis Profile IgG: 11 Antigens Test is to detect myositis-specific autoantibodies (MSAs) that are critical for diagnosing autoimmune myositis. These antibodies, such as Mi-2, Ku, PM-SCL, Jo-1, SRP, PL-7, PL-12, EJ, OJ, and Ro-52, target key regulatory intracellular processes. Their identification helps classify the disease subtype, predict clinical phenotypes, and guide targeted treatment strategies, improving patient outcomes.
- Test Code
- 1283
- Price
- ₹10,000
- Sample Type
- Serum
- Result Time
- Same day
- Fasting Required
- No
- Method
- Immunoblot
Sample Collection
No special preparation is required for this test. Ensure adequate hydration and inform the healthcare provider about any medications or supplements being taken.
Method: Venipuncture
Laboratory Analysis
A blood sample will be collected via venipuncture from a vein in your arm by a trained phlebotomist. The procedure typically takes a few minutes.
Report Delivery
After blood collection, apply gentle pressure to the puncture site with a cotton ball to prevent bleeding and bruising. You can resume normal activities immediately. Keep the site clean and dry.
Timeline: Same day
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Myositis Profile IgG: 11 Antigens Test is to detect myositis-specific autoantibodies (MSAs) that are critical for diagnosing autoimmune myositis. These antibodies, such as Mi-2, Ku, PM-SCL, Jo-1, SRP, PL-7, PL-12, EJ, OJ, and Ro-52, target key regulatory intracellular processes. Their identification helps classify the disease subtype, predict clinical phenotypes, and guide targeted treatment strategies, improving patient outcomes.
How to Prepare
- Sample type: Serum
- Volume: 2 mL (1 mL minimum)
- Container: Serum Separator Tube (SST)
- Handling: Ship refrigerated or frozen
- Stability: Room temperature up to 8 hours, refrigerated up to 2 weeks, frozen up to 4 weeks
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test detects specific antibodies crucial for diagnosing autoimmune myositis, helping to identify disease subtypes and guide personalized treatment plans."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or visibly lipemic samples
- Insufficient sample volume less than 1 mL
- Improper storage or delayed shipment beyond stability limits
- Sample collected in incorrect container
Understanding Your Results
Positive for one or more specific antigens (e.g., Jo-1, Mi-2)
Indicates the presence of myositis-specific antibodies, supporting a diagnosis of autoimmune myositis. The specific antibody may correlate with a particular clinical phenotype and guide treatment.
Negative for all antigens
Myositis-specific IgG antibodies not detected. This does not rule out myositis entirely, as some patients may have antibody-negative disease or other causes. Further clinical evaluation is recommended.
Weak positive or borderline
May require repeat testing or correlation with clinical findings. Consultation with a specialist is advised for interpretation.
Consult a rheumatologist or immunologist if you experience symptoms such as persistent muscle weakness, difficulty with daily activities, unexplained fatigue, or joint pain. Early consultation is crucial for timely diagnosis and management, especially if test results are positive or symptoms persist.
Limitations
- ⚠This test may not detect all subtypes of myositis or rare antibody profiles
- ⚠Results must be interpreted in conjunction with clinical symptoms, medical history, and other diagnostic tests
- ⚠A negative result does not completely rule out myositis, as not all patients have detectable MSAs
- ⚠The test is specific for IgG antibodies; other antibody classes are not assessed
Risks & Considerations
- ●Minor bruising or pain at the needle insertion site
- ●Rare risk of infection or excessive bleeding
- ●Dizziness or fainting during blood draw, though uncommon
Interfering Factors
- ●Medications that modulate the immune system, such as immunosuppressants
- ●Presence of other autoimmune conditions that may produce cross-reactive antibodies
- ●Recent infections or inflammatory states that could affect antibody levels
- ●Hemolyzed or lipemic samples may interfere with test accuracy
Compare With Similar Tests
| Test | Myositis Profile IgG: 11 Antigens Test | Creatine Kinase (CK) Test | Aldolase Test | Anti-Jo-1 Antibody Test | Electromyography (EMG) | Muscle Biopsy |
|---|---|---|---|---|---|---|
| Comparison | Myositis Profile IgG: 11 Antigens Test | Measures muscle enzyme levels; elevated in muscle damage but not specific to myositis. | Another muscle enzyme test; used alongside CK for muscle inflammation assessment. | Detects a specific myositis antibody; part of this broader profile. | Assesses electrical activity in muscles; helps diagnose neuromuscular disorders but not specific to myositis antibodies. | Invasive procedure to examine muscle tissue; gold standard for confirming myositis histologically. |
Frequently Asked Questions
What is the Myositis Profile IgG: 11 Antigens Test?
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