NIPT Advanced for 23 Chromosomes Test
Short Name: NIPT Advanced 23
Also known as: NIPT Advanced, Non-Invasive Prenatal Screening for all chromosomes, cfDNA screening for 23 chromosomes
NIPT Advanced for 23 Chromosomes Test test available at DNA Labs India for ₹13,000. Uses Next-Generation Sequencing (NGS), Cell-Free DNA Analysis on Blood samples. Results in Results are typically available within 5-7 working days after the sample reaches the laboratory. You will receive a notification via email or WhatsApp when your report is ready.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of the NIPT Advanced for 23 Chromosomes test is to screen for fetal chromosomal abnormalities, including aneuploidies (e.g., Down syndrome, Edwards syndrome, Patau syndrome), sex chromosome abnormalities (e.g., Turner syndrome, Klinefelter syndrome), and certain microdeletion syndromes. It helps expectant parents and healthcare providers assess the risk of genetic disorders early in pregnancy, enabling informed decisions about further diagnostic testing and pregnancy management. The test is non-invasive, eliminating the risk of miscarriage associated with invasive procedures, and provides high accuracy, reducing unnecessary invasive tests. It is intended for all pregnant women, especially those with risk factors such as advanced maternal age (≥35 years), abnormal maternal serum screening, or ultrasound anomalies. The test also aids in determining fetal sex and detecting sex chromosome aneuploidies. By offering a comprehensive analysis of all 23 chromosomes, it provides a broader genetic evaluation than standard NIPT, making it a valuable tool in prenatal care.
- Test Code
- 6294
- CPT Code
- 81420
- ICD Code
- Z36.89
- Price
- ₹13,000
- Sample Type
- Blood
- Result Time
- Results are typically available within 5-7 working days after the sample reaches the laboratory. You will receive a notification via email or WhatsApp when your report is ready.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Cell-Free DNA Analysis
Sample Collection
No special preparation is required. Inform your healthcare provider about any medications, supplements, or medical conditions. It is recommended to have the test after 10 weeks of gestation. Avoid eating a heavy meal immediately before the blood draw, though fasting is not necessary.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will draw approximately 10 mL of blood from a vein in your arm. The procedure is quick and causes minimal discomfort. For home collection, the phlebotomist will visit your location at a scheduled time.
Report Delivery
You can resume normal activities immediately. There are no restrictions. The blood sample will be transported to the laboratory for analysis. Results are typically available within 5-7 working days and will be shared via email, WhatsApp, or the online portal.
Timeline: Results are typically available within 5-7 working days after the sample reaches the laboratory. You will receive a notification via email or WhatsApp when your report is ready.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the NIPT Advanced for 23 Chromosomes test is to screen for fetal chromosomal abnormalities, including aneuploidies (e.g., Down syndrome, Edwards syndrome, Patau syndrome), sex chromosome abnormalities (e.g., Turner syndrome, Klinefelter syndrome), and certain microdeletion syndromes. It helps expectant parents and healthcare providers assess the risk of genetic disorders early in pregnancy, enabling informed decisions about further diagnostic testing and pregnancy management. The test is non-invasive, eliminating the risk of miscarriage associated with invasive procedures, and provides high accuracy, reducing unnecessary invasive tests. It is intended for all pregnant women, especially those with risk factors such as advanced maternal age (≥35 years), abnormal maternal serum screening, or ultrasound anomalies. The test also aids in determining fetal sex and detecting sex chromosome aneuploidies. By offering a comprehensive analysis of all 23 chromosomes, it provides a broader genetic evaluation than standard NIPT, making it a valuable tool in prenatal care.
How to Prepare
- Ensure the blood sample is collected in the provided Cell-Free DNA BCT tube
- Do not shake the tube vigorously; invert gently to mix
- Maintain the sample at room temperature (15-25°C) until pickup
- Schedule the collection at least 10 weeks after the last menstrual period
- Inform the phlebotomist if you have had a blood transfusion or transplant in the past 3 months
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"NIPT Advanced is a valuable screening tool for all pregnant women, especially those with risk factors. It provides high accuracy for common aneuploidies and also screens for other chromosomal imbalances, aiding in informed decision-making."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted sample
- Insufficient blood volume (< 5 mL)
- Sample collected before 10 weeks of gestation
- Sample tube not properly labeled
- Sample received after 7 days of collection
- Maternal weight > 250 lbs (may require special handling)
Understanding Your Results
Reduced likelihood of chromosomal aneuploidies; however, this does not rule out all genetic conditions. Routine prenatal care should continue.
Increased risk for Down syndrome, Edwards syndrome, or Patau syndrome respectively. Confirmatory invasive testing is recommended.
Possible sex chromosome aneuploidy (e.g., Turner, Klinefelter). Genetic counseling and confirmatory testing advised.
Possible rare aneuploidy or structural abnormality. Confirmatory testing and specialist consultation required.
Insufficient fetal DNA for reliable analysis. A repeat blood draw may be necessary.
Consult your obstetrician or genetic counselor if you receive a high-risk result, if the test fails due to low fetal fraction, or if you have any concerns about your pregnancy. Also, seek medical advice if you experience any unusual symptoms or have questions about the implications of the test results.
Limitations
- ⚠Screening test, not diagnostic; abnormal results require confirmation via invasive testing
- ⚠May not detect all chromosomal abnormalities (e.g., balanced translocations, low-level mosaicism)
- ⚠Accuracy is reduced in multiple pregnancies
- ⚠Fetal fraction below 4% may lead to test failure or inaccurate results
- ⚠Not recommended for women with known chromosomal abnormalities in the mother
- ⚠Does not detect neural tube defects or other structural anomalies
Risks & Considerations
- ●No physical risks associated with the blood draw
- ●Possible bruising or discomfort at the puncture site
- ●Emotional stress due to potential high-risk results
- ●False positive or false negative results (rare but possible)
Interfering Factors
- ●Maternal obesity (BMI > 40) may reduce fetal fraction
- ●Multiple gestation (twins, triplets) may affect accuracy
- ●Maternal chromosomal abnormalities (e.g., mosaicism)
- ●Vanishing twin syndrome
- ●Recent blood transfusion or organ transplant
- ●Maternal malignancy (rarely can cause false positives)
Compare With Similar Tests
| Test | NIPT Advanced for 23 Chromosomes | Standard NIPT | Amniocentesis | Chorionic Villus Sampling (CVS) |
|---|---|---|---|---|
| Comparison | NIPT Advanced for 23 Chromosomes | Standard NIPT typically screens for chromosomes 21, 18, 13, and sex chromosomes. NIPT Advanced screens all 23 chromosomes, providing broader coverage. | Amniocentesis is a diagnostic test that samples amniotic fluid. It is invasive and carries a small risk of miscarriage (0.1-0.3%). NIPT is non-invasive and has no miscarriage risk. | CVS is an invasive diagnostic test performed at 10-13 weeks. It has a similar miscarriage risk to amniocentesis. NIPT is non-invasive and can be done earlier. |
Frequently Asked Questions
What is NIPT Advanced for 23 Chromosomes?
When can I take this test?
Is fasting required for the test?
How accurate is the NIPT Advanced test?
What is the cost of the test?
Is home sample collection available?
How long does it take to get results?
Can this test detect all genetic disorders?
Is NIPT Advanced a diagnostic test?
What is the difference between NIPT Advanced and standard NIPT?
Are there any risks to the mother or baby?
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