Oncomine Tumor Mutation Burden [TMB] + Microsatellite Instability (MSI) Test
Short Name: Oncomine TMB + MSI
Also known as: TMB and MSI testing, Oncomine TMB/MSI assay
Oncomine Tumor Mutation Burden [TMB] + Microsatellite Instability (MSI) Test test available at DNA Labs India for ₹52,500. Uses NGS, Sanger Sequencing on Tumor tissue + Peripheral Blood samples. Results in 2-3 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of Oncomine TMB + MSI testing is to identify genetic mutations in tumors that predict response to immunotherapy and guide personalized cancer treatment. It helps determine the tumor mutation burden and microsatellite instability status, which are critical for selecting appropriate therapies and improving patient outcomes.
- Test Code
- 3136
- Price
- ₹52,500
- Sample Type
- Tumor tissue + Peripheral Blood
- Result Time
- 2-3 weeks
- Fasting Required
- No
- Method
- NGS, Sanger Sequencing
Sample Collection
A doctor's prescription is required for this test, except in cases of surgery, pregnancy, or travel abroad. Ensure proper documentation and discuss any medications with your physician.
Method: Biopsy for tumor tissue, venipuncture for blood
Laboratory Analysis
Tumor tissue is collected via biopsy or surgical resection, and blood is drawn via venipuncture. The procedure is performed by trained healthcare professionals.
Report Delivery
Samples are processed and sent to the lab. Patients may experience minor discomfort from biopsy or blood draw, which typically resolves quickly.
Timeline: 2-3 weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of Oncomine TMB + MSI testing is to identify genetic mutations in tumors that predict response to immunotherapy and guide personalized cancer treatment. It helps determine the tumor mutation burden and microsatellite instability status, which are critical for selecting appropriate therapies and improving patient outcomes.
How to Prepare
- Obtain a valid doctor's prescription unless exempted
- For tumor tissue, ensure proper fixation in paraffin blocks
- For blood, use an EDTA vacutainer and collect 3 ml
- Label samples correctly with patient details
- Transport samples at ambient temperature as specified
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is crucial for personalized cancer therapy, helping to identify patients who may benefit from immunotherapy based on tumor mutation burden and microsatellite instability status."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Samples without proper labeling or documentation
- Insufficient sample volume or quality
- Samples not collected as per instructions
Understanding Your Results
High TMB (>10 mut/Mb)
May indicate a higher likelihood of response to immune checkpoint inhibitors, such as pembrolizumab.
Low TMB (<5 mut/Mb)
May suggest lower response to immunotherapy; other treatment options should be considered.
MSI-High (MSI-H)
Associated with Lynch syndrome and better response to immunotherapy; genetic counseling may be recommended.
MSI-Low (MSI-L) or Microsatellite Stable (MSS)
Less likely to benefit from immunotherapy; focus on other targeted therapies or chemotherapy.
Consult your doctor if you experience symptoms of cancer such as unexplained weight loss, fatigue, or persistent cough, or if you have a family history of cancer. After receiving test results, discuss them with your oncologist for appropriate treatment planning.
Limitations
- ⚠Test results are not standalone diagnostic tools and must be correlated with clinical findings
- ⚠False positives or negatives may occur due to technical limitations
- ⚠Not all tumors with high TMB or MSI-H respond to immunotherapy
Risks & Considerations
- ●Minor pain or bruising at biopsy or blood draw site
- ●Risk of infection from invasive procedures
- ●Psychological stress from test results
- ●Potential for inconclusive results requiring repeat testing
Interfering Factors
- ●Insufficient tumor cellularity in sample
- ●DNA degradation due to improper storage
- ●Contamination during sample collection or processing
Frequently Asked Questions
What is Oncomine TMB + MSI testing?
Why is this test important for cancer patients?
What is the cost of the test?
How is the sample collected?
Is fasting required before the test?
How long does it take to get results?
What does a high TMB result mean?
What does MSI-High indicate?
Is the test covered by insurance?
Can I get home sample collection?
What are the risks of the test?
How should I prepare for the test?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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