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PML/RARA (AML - M3 [APML]) Test

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PML/RARA (AML - M3 [APML]) Test

Short Name: PML/RARA Gene Fusion Test

Also known as: APML Gene Fusion Test, PML-RARA Translocation Test

PML/RARA (AML - M3 [APML]) Test test available at DNA Labs India for ₹5,250. Uses FISH (Fluorescence In Situ Hybridization) on Bone Marrow / Peripheral blood samples. Results in 3-4 days. Free home collection in 300+ cities across India.

Oncology🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To detect the PML/RARA gene fusion for diagnosis, prognosis, and monitoring of Acute Promyelocytic Leukemia (APML), guiding targeted treatment decisions.

Test Code
3152
Price
₹5,250
Sample Type
Bone Marrow / Peripheral blood
Result Time
3-4 days
Fasting Required
No
Method
FISH (Fluorescence In Situ Hybridization)
Step 1

Sample Collection

Inform your doctor about any medications, recent procedures, or health conditions. Ensure a valid prescription is available.

Method: Peripheral Blood Venipuncture or Bone Marrow Aspiration

Step 2

Laboratory Analysis

For peripheral blood, a venipuncture is performed; for bone marrow, aspiration under local anesthesia. The process takes about 15-30 minutes.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Avoid strenuous activity for a few hours, especially after bone marrow biopsy.

Timeline: 3-4 days

Patient Instructions

1
Before the Test:Ensure prescription is available and inform the lab of any relevant medical history.
2
During the Test:Sample collection as per standard procedures; minimal discomfort expected.
3
After the Test:Resume normal activities unless advised otherwise. Monitor the collection site for any adverse effects.

About This Test

Who Should Get This Test

To detect the PML/RARA gene fusion for diagnosis, prognosis, and monitoring of Acute Promyelocytic Leukemia (APML), guiding targeted treatment decisions.

How to Prepare

  • Carry a doctor's prescription
  • Wear comfortable clothing
  • Stay hydrated
  • Avoid blood thinners if advised by physician

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Early detection of PML/RARA fusion is critical for targeted therapy in APML, significantly improving patient outcomes with treatments like ATRA and arsenic trioxide."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBone Marrow / Peripheral blood
Sample Volume2 ml
ContainerSodium Heparin Vacutainer
Collection MethodPeripheral Blood Venipuncture or Bone Marrow Aspiration

Sample Stability

Room Temperature
Refrigerated (2-8°C)
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient volume
  • Incorrect container or anticoagulant
  • Unlabeled sample

Understanding Your Results

Results indicate the presence or absence of PML/RARA gene fusion, which is diagnostic for APML.
📊

Positive

PML/RARA fusion detected, confirming APML. Immediate consultation with an oncologist for targeted therapy is recommended.

📊

Negative

No PML/RARA fusion detected. Consider other diagnostic tests if clinical suspicion remains.

⚠️ When to Consult a Doctor:

If you experience symptoms like unexplained bleeding, fatigue, or fever, or if test results are abnormal, consult an oncologist promptly.

Limitations

  • ⚠Cannot detect all subtypes of AML
  • ⚠Requires specialized equipment and expertise
  • ⚠False negatives possible in low-quality samples
  • ⚠Not a standalone diagnostic; clinical correlation needed

Risks & Considerations

  • ●Minor bruising or pain at puncture site
  • ●Infection risk for bone marrow biopsy
  • ●Rare allergic reaction to local anesthesia
  • ●Dizziness or fainting during blood draw

Interfering Factors

  • ●Sample contamination
  • ●Improper sample handling
  • ●Recent blood transfusion
  • ●Hemolyzed sample

Compare With Similar Tests

TestPML/RARA (AML - M3 [APML])Bone Marrow BiopsyFlow CytometryCytogenetic Analysis
ComparisonPML/RARA (AML - M3 [APML])More invasive but provides detailed cellular morphology and architecture.Used for immunophenotyping of leukemia cells but does not detect specific gene fusions.Detects chromosomal abnormalities but may not identify the PML/RARA fusion specifically.

Frequently Asked Questions

What is the PML/RARA test?
The PML/RARA test detects the PML/RARA gene fusion, which is characteristic of Acute Promyelocytic Leukemia (APML), a subtype of AML.
Why is the PML/RARA test important?
It enables early and accurate diagnosis of APML, allowing for targeted therapy that significantly improves treatment outcomes.
How is the PML/RARA test performed?
The test uses Fluorescence In Situ Hybridization (FISH) on a bone marrow or peripheral blood sample to identify the gene fusion.
What sample is required for the PML/RARA test?
A bone marrow aspirate or peripheral blood sample collected in a Sodium Heparin Vacutainer.
How long does it take to get PML/RARA test results?
Results are typically available within 3-4 days after sample collection.
What does a positive PML/RARA test result mean?
A positive result confirms the presence of PML/RARA fusion, indicating APML. Immediate consultation with an oncologist is recommended.
What does a negative PML/RARA test result mean?
A negative result means no PML/RARA fusion was detected. Further tests may be needed if symptoms persist.
Is the PML/RARA test painful?
For blood draw, minimal discomfort; for bone marrow biopsy, local anesthesia is used to reduce pain.
Are there any risks associated with the PML/RARA test?
Risks include minor bruising, infection (for bone marrow biopsy), and rare allergic reactions. These are generally low.
How should I prepare for the PML/RARA test?
No special preparation is needed, but inform your doctor about medications and ensure a prescription is available.
Can the PML/RARA test be done at home?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What is the cost of the PML/RARA test in India?
The cost is INR 5250 at DNA Labs India, with free home collection included.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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