PML/RARA Quantitative [Single Form] Test
Short Name: PML/RARA Quantitative
Also known as: PML-RARA Fusion Gene Test, Acute Promyelocytic Leukemia Genetic Test, PML-RARA Quantitative PCR
PML/RARA Quantitative [Single Form] Test test available at DNA Labs India for ₹6,300. Uses Real Time PCR on Bone marrow / Peripheral blood samples. Results in Results are typically available within 2-3 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the PML/RARA Quantitative test is to detect the presence and quantify the level of PML/RARA gene fusion in patients suspected of having Acute Promyelocytic Leukemia (APL). It helps in confirming diagnosis, assessing disease burden, monitoring response to therapy, and detecting minimal residual disease.
- Test Code
- 3154
- Price
- ₹6,300
- Sample Type
- Bone marrow / Peripheral blood
- Result Time
- Results are typically available within 2-3 days after sample receipt.
- Fasting Required
- No
- Method
- Real Time PCR
Sample Collection
Ensure the patient has a valid doctor's prescription. Inform the lab of any medications or recent treatments. No specific fasting is required, but follow general pre-test instructions.
Method: Venipuncture
Laboratory Analysis
Sample collection via venipuncture using an EDTA vacutainer. For bone marrow, aspirate under sterile conditions. Label samples correctly and transport immediately to the lab.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Store samples at recommended temperatures and avoid delays in transport. Monitor for any adverse reactions.
Timeline: Results are typically available within 2-3 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the PML/RARA Quantitative test is to detect the presence and quantify the level of PML/RARA gene fusion in patients suspected of having Acute Promyelocytic Leukemia (APL). It helps in confirming diagnosis, assessing disease burden, monitoring response to therapy, and detecting minimal residual disease.
How to Prepare
- Use aseptic technique for collection
- Collect 4 ml of peripheral blood or bone marrow in EDTA tube
- Mix sample gently to prevent clotting
- Transport immediately at 2-8°C or as per lab guidelines
- Include proper documentation and patient details
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is essential for diagnosing and monitoring Acute Promyelocytic Leukemia, guiding treatment decisions and assessing response to therapy."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Insufficient sample volume
- Improper labeling or missing documentation
- Samples not transported within stability period
Understanding Your Results
Positive (Detected)
Confirms diagnosis of APL. High levels may indicate active disease; decreasing levels suggest response to therapy.
Negative (Not Detected)
No PML/RARA fusion detected. May indicate absence of APL or undetectable levels; clinical correlation is needed.
Quantitative Value
Measured in copies or percentage. Compare with baseline and follow-up values to assess treatment response or relapse.
Consult a doctor if symptoms such as unexplained bleeding, fatigue, or fever persist, or if test results are abnormal. Regular follow-up is recommended for diagnosed APL patients.
Limitations
- ⚠May not detect all rare variants of PML/RARA fusion
- ⚠Requires confirmatory testing in some cases
- ⚠Quantitative accuracy depends on sample quality
- ⚠Not suitable for screening in asymptomatic individuals without clinical indication
Risks & Considerations
- ●Minimal risks from blood draw: bruising, infection, or dizziness
- ●Bone marrow collection may cause discomfort or rare complications
Interfering Factors
- ●Contaminated or degraded samples
- ●Improper sample storage or transport
- ●Presence of inhibitors in the sample
- ●Recent blood transfusions affecting nucleic acid quality
Compare With Similar Tests
| Test | PML/RARA Quantitative [Single Form] | BCR-ABL Quantitative | FLT3 Mutation Analysis | Cytogenetic Analysis | Flow Cytometry for Leukemia |
|---|---|---|---|---|---|
| Comparison | PML/RARA Quantitative [Single Form] | Detects BCR-ABL fusion for chronic myeloid leukemia, different genetic marker. | Identifies FLT3 mutations in AML, complementary for leukemia subtyping. | Examines chromosome abnormalities; less specific than molecular tests for PML/RARA. | Assesses cell surface markers; used alongside genetic tests for comprehensive diagnosis. |
Frequently Asked Questions
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