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Prenatal Diagnostic Screening by Karyotyping + FISH (for any one 13, 18, 21, X and Y) Test

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Prenatal Diagnostic Screening by Karyotyping + FISH (for any one 13, 18, 21, X and Y) Test

Short Name: Prenatal Karyotyping + FISH

Also known as: Prenatal FISH Test, Karyotyping with FISH, Chromosomal Analysis Prenatal

Prenatal Diagnostic Screening by Karyotyping + FISH (for any one 13, 18, 21, X and Y) Test test available at DNA Labs India for ₹13,500. Uses Cell Culture, Fluorescence In Situ Hybridization (FISH) on Amniotic fluid / Bits of Chorionic tissue samples. Results in 15-20 days. Free home collection in 300+ cities across India.

Diagnostic ScreeningFemaleAdult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect chromosomal abnormalities in the fetus, such as trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), trisomy 13 (Patau syndrome), and sex chromosome aneuploidies, to provide early diagnosis and guide pregnancy management.

Test Code
3169
Price
₹13,500
Sample Type
Amniotic fluid / Bits of Chorionic tissue
Result Time
15-20 days
Fasting Required
No
Method
Cell Culture, Fluorescence In Situ Hybridization (FISH)
Step 1

Sample Collection

Consult with your healthcare provider. No specific preparation required, but follow any instructions given.

Method: Amniocentesis or Chorionic Villus Sampling (CVS)

Step 2

Laboratory Analysis

Sample is collected via amniocentesis or CVS under ultrasound guidance by a trained professional.

Step 3

Report Delivery

Rest for a short period. Monitor for any signs of infection or complications.

Timeline: 15-20 days

Patient Instructions

1
Before the Test:Discuss with your doctor. No fasting required.
2
During the Test:Sample collection procedure takes about 30 minutes.
3
After the Test:Resume normal activities. Await results.

About This Test

Who Should Get This Test

The purpose of this test is to detect chromosomal abnormalities in the fetus, such as trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), trisomy 13 (Patau syndrome), and sex chromosome aneuploidies, to provide early diagnosis and guide pregnancy management.

How to Prepare

  • Ensure sterile containers are used
  • Label samples correctly
  • Transport to lab promptly

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for early detection of chromosomal abnormalities, allowing for informed decision-making in prenatal care."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeAmniotic fluid / Bits of Chorionic tissue
Sample Volume2 sterile tubes (15 ml each) or sterile tissue culture container
ContainerSterile tubes or tissue culture container with normal saline or culture media
Collection MethodAmniocentesis or Chorionic Villus Sampling (CVS)

Sample Stability

Store at room temperature
Process within 24 hours for best results
Sample Rejection Criteria:
  • Leaked or contaminated container
  • Incorrect sample type
  • Insufficient volume

Understanding Your Results

Results indicate whether chromosomal abnormalities are detected. Normal results show no abnormalities, while abnormal results may indicate conditions like Down syndrome.
📊

Normal

No chromosomal abnormalities detected for tested chromosomes.

📊

Abnormal

Chromosomal abnormality detected, such as trisomy or monosomy. Consult a genetic counselor.

⚠️ When to Consult a Doctor:

If results are abnormal or if you have concerns about the test or pregnancy.

Limitations

  • ⚠Cannot detect single gene disorders
  • ⚠Limited to specific chromosomes (13, 18, 21, X, Y)
  • ⚠Risk of false positives or negatives

Risks & Considerations

  • ●Risk of miscarriage (1 in 200-300 for amniocentesis)
  • ●Infection
  • ●Leakage of amniotic fluid

Interfering Factors

  • ●Contaminated sample
  • ●Insufficient cell growth
  • ●Maternal cell contamination

Compare With Similar Tests

TestPrenatal Diagnostic Screening by Karyotyping + FISH (for any one 13, 18, 21, X and Y)
ComparisonPrenatal Diagnostic Screening by Karyotyping + FISH (for any one 13, 18, 21, X and Y)

Frequently Asked Questions

What is Prenatal Diagnostic Screening by Karyotyping + FISH?
It is a test that examines the chromosomes of a fetus using karyotyping and FISH to detect abnormalities like Down syndrome.
When is this test recommended?
It is recommended for high-risk pregnancies, such as when the mother is over 35, has a family history of genetic disorders, or abnormal ultrasound findings.
How is the sample collected?
The sample is collected via amniocentesis or chorionic villus sampling (CVS) by a healthcare professional.
What are the risks associated with this test?
Risks include a small chance of miscarriage, infection, or leakage of amniotic fluid.
How long does it take to get the results?
Results are typically available within 15-20 days.
What do normal results mean?
Normal results indicate no chromosomal abnormalities were detected for the tested chromosomes.
What do abnormal results mean?
Abnormal results may indicate a chromosomal condition such as trisomy 21, 18, or 13. Consult a genetic counselor for interpretation.
Can this test detect all genetic disorders?
No, it only detects abnormalities in chromosomes 13, 18, 21, X, and Y. Other genetic disorders may require different tests.
Is the test painful?
The collection procedure may cause mild discomfort, but it is generally well-tolerated.
What is the cost of the test?
The test costs INR 13500 at DNA Labs India, with free home sample collection.
Is home collection available?
Yes, free home sample collection is available for online bookings across India.
How accurate is the test?
Karyotyping and FISH are highly accurate for detecting chromosomal abnormalities, but no test is 100% infallible.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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