Sm (Smith) Antibody IgG Test
Short Name: Sm Antibody IgG
Also known as: Anti-Smith Antibody IgG, Anti-Sm Test, Smith Antibody, Anti-Sm IgG
Sm (Smith) Antibody IgG Test test available at DNA Labs India for ₹1,135. Uses Enzyme Immunoassay on Serum samples. Results in Reports are available the same day if the sample reaches the laboratory by 9 am on Tuesday or Friday. In other cases, reports may be delivered within 24 hours.. Free home collection in 300+ cities across India.
Overview
The purpose of the Sm (Smith) Antibody IgG test is to support a clinical diagnosis of systemic lupus erythematosus and other autoimmune connective tissue disorders, especially in patients who have a positive antinuclear antibody (ANA) test and compatible symptoms.
- Test Code
- 3644
- CPT Code
- 86235
- ICD Code
- M32.9
- Price
- ₹1,135
- Sample Type
- Serum
- Result Time
- Reports are available the same day if the sample reaches the laboratory by 9 am on Tuesday or Friday. In other cases, reports may be delivered within 24 hours.
- Fasting Required
- No
- Method
- Enzyme Immunoassay
Sample Collection
No special preparation required. Inform your doctor if you are taking any medications, as certain drugs may affect the immune response.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will draw a small amount of blood from a vein in your arm. The procedure is quick and causes minimal discomfort.
Report Delivery
You can resume normal activities immediately. There are no specific restrictions.
Timeline: Reports are available the same day if the sample reaches the laboratory by 9 am on Tuesday or Friday. In other cases, reports may be delivered within 24 hours.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Sm (Smith) Antibody IgG test is to support a clinical diagnosis of systemic lupus erythematosus and other autoimmune connective tissue disorders, especially in patients who have a positive antinuclear antibody (ANA) test and compatible symptoms.
How to Prepare
- No fasting required
- No special preparation required
- Blood sample should be collected before starting immunosuppressive therapy if possible (consult physician)
Doctor's Notes
"Anti-Sm antibodies are highly specific for SLE and help in supporting the diagnosis when clinical features and ANA positivity are present."
Test Parameters & Specifications
Sample Stability
- Hemolyzed or grossly lipemic samples
- Improper sample labeling
- Samples not stored or shipped at appropriate temperature
Understanding Your Results
Negative
No detectable anti-Sm antibodies. A negative result does not exclude SLE; the diagnosis should be based on clinical criteria and other serological tests.
Positive
Detection of anti-Sm antibodies supports a diagnosis of systemic lupus erythematosus. Anti-Sm is highly specific for SLE and is present in about 30% of patients. Further evaluation is recommended.
If you experience persistent fatigue, fever, joint pain, facial rash, hair loss, oral ulcers, or unexplained weight loss, consult a physician for evaluation. Early diagnosis and treatment of autoimmune diseases is critical.
Limitations
- ⚠A negative result does not rule out systemic lupus erythematosus
- ⚠Anti-Sm antibodies may rarely be present in other autoimmune conditions
- ⚠Results should be correlated with clinical symptoms and other laboratory findings
Risks & Considerations
- ●Mild pain or bruising at the needle site
- ●Slight dizziness
- ●Infection (rare)
Interfering Factors
- ●No special preparation is needed. However, certain medications may affect antibody levels.
Compare With Similar Tests
| Test | Sm (Smith) Antibody IgG Test | |||
|---|---|---|---|---|
| Comparison | Sm (Smith) Antibody IgG Test | ANA is a screening test for many autoimmune diseases. Anti-Sm is highly specific for SLE and is ordered when ANA is positive and clinical features suggest lupus. | Anti-dsDNA antibodies correlate with SLE disease activity and renal involvement, whereas anti-Sm is specific for SLE but not closely linked to disease activity. | The ENA panel includes multiple antibodies, including Sm and RNP. A positive anti-Sm within the ENA panel strongly supports SLE. |
Frequently Asked Questions
What is the Sm (Smith) Antibody IgG test used for?
What does a positive Sm antibody mean?
Is a negative Sm antibody result always normal?
What is the cost of the Sm Antibody test in India?
Is fasting required before the Sm Antibody test?
What is the sample type for the test?
How long does it take to get the report?
Where can I get this test done at home?
Which conditions are associated with Sm antibodies?
Do I need a doctor's prescription for this test?
What are the other tests for lupus besides Sm antibody?
How should I interpret my test results?
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