Tissue Transglutaminase (tTG) Antibody IgA Test
Short Name: tTG IgA Test
Also known as: Anti-tTG IgA Test, Tissue Transglutaminase IgA Antibody Test, Celiac Disease Antibody Test
Tissue Transglutaminase (tTG) Antibody IgA Test test available at DNA Labs India for ₹1,170. Uses Enzyme Immunoassay on Serum samples. Results in Same-day reports available if sample is received by 9 am.. Free home collection in 300+ cities across India.
Overview
To diagnose celiac disease by detecting antibodies against tissue transglutaminase, monitor treatment adherence to a gluten-free diet, and screen for related conditions like dermatitis herpetiformis.
- Test Code
- 1442
- Price
- ₹1,170
- Sample Type
- Serum
- Result Time
- Same-day reports available if sample is received by 9 am.
- Fasting Required
- No
- Method
- Enzyme Immunoassay
Sample Collection
No special preparation required. Fasting is not necessary.
Method: Venipuncture
Laboratory Analysis
A healthcare professional will draw a blood sample from a vein in your arm using standard venipuncture.
Report Delivery
Apply pressure to the puncture site to stop bleeding. Resume normal activities immediately.
Timeline: Same-day reports available if sample is received by 9 am.
Patient Instructions
About This Test
Who Should Get This Test
To diagnose celiac disease by detecting antibodies against tissue transglutaminase, monitor treatment adherence to a gluten-free diet, and screen for related conditions like dermatitis herpetiformis.
How to Prepare
- Collect 2 mL (minimum 1 mL) of blood in a serum separator tube (SST).
- Ship samples refrigerated or frozen as specified.
- Ensure proper labeling and handling to maintain sample integrity.
Doctor's Notes
"The tTG IgA test is essential for accurate diagnosis of celiac disease and monitoring treatment adherence through gluten-free diet. Early detection prevents long-term complications."
Test Parameters & Specifications
Sample Stability
- Hemolyzed or lipemic samples may be rejected.
- Insufficient sample volume.
- Improper storage or labeling.
Understanding Your Results
Negative (<20 U/mL)
No significant antibodies detected. Celiac disease is unlikely, but clinical symptoms may require further evaluation.
Positive (≥20 U/mL)
Elevated antibodies indicate possible celiac disease. Confirm with biopsy or additional serological tests. Consult a gastroenterologist.
Borderline or Indeterminate
Repeat testing or additional tests recommended. Consider total IgA levels and clinical context.
If test results are positive, or if you experience persistent symptoms like abdominal pain, diarrhea, or unexplained weight loss despite negative results.
Limitations
- ⚠False positives can occur in other autoimmune disorders.
- ⚠The test cannot distinguish between active and latent celiac disease.
- ⚠Positive results require confirmation with biopsy or additional tests for definitive diagnosis.
Risks & Considerations
- ●Minimal risks such as slight bruising, pain, or dizziness at the puncture site.
- ●Rarely, infection or hematoma at the collection site.
Interfering Factors
- ●IgA deficiency may lead to false-negative results; total IgA levels may be tested concurrently.
- ●Recent gluten exposure or diet changes can affect antibody levels.
- ●Other autoimmune conditions (e.g., Type 1 diabetes, thyroid disease) may cause mild elevations.
Compare With Similar Tests
| Test | Tissue Transglutaminase (tTG) Antibody IgA Test | Total IgA Test | Deamidated Gliadin Peptide (DGP) Antibodies | Endomysial Antibody (EMA) Test | HLA DQ2/DQ8 Genetic Test |
|---|---|---|---|---|---|
| Comparison | Tissue Transglutaminase (tTG) Antibody IgA Test | Checks for IgA deficiency, which can affect tTG IgA test accuracy. | Another antibody test for celiac disease, useful in IgA-deficient patients. | Highly specific for celiac disease but more labor-intensive; often used as confirmatory. | Identifies genetic risk; negative result largely excludes celiac disease. |
Frequently Asked Questions
What is the Tissue Transglutaminase (tTG) Antibody IgA Test?
Why is this test performed?
How is the test performed?
What does a positive result mean?
What does a negative result mean?
Is fasting required for the test?
How much does the tTG IgA Test cost in India?
How long does it take to get results?
Can this test be done at home?
What are the symptoms of celiac disease?
Are there any risks or side effects from the test?
What should I do after receiving positive results?
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