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XRCC3 Gene Breast cancer, susceptibility to NGS Genetic Test

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XRCC3 Gene Breast cancer, susceptibility to NGS Genetic Test

XRCC3 Gene Breast cancer, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestFemaleAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the XRCC3 gene that are associated with increased susceptibility to breast cancer, enabling early risk assessment and preventive strategies.

Test Code
2838
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history review and genetic counseling session recommended to draw a pedigree chart of family members affected.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collection via venipuncture or use of FTA card for one drop of blood.

Step 3

Report Delivery

Sample is sent to the laboratory for NGS analysis and report generation.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and informed consent are essential before testing.
2
During the Test:Sample collection and processing in a certified laboratory.
3
After the Test:Report delivery and consultation to discuss results and next steps.

About This Test

Who Should Get This Test

To identify mutations in the XRCC3 gene that are associated with increased susceptibility to breast cancer, enabling early risk assessment and preventive strategies.

How to Prepare

  • No fasting required
  • Ensure proper identification and consent
  • Follow standard phlebotomy procedures

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for breast cancer susceptibility is crucial for early intervention, personalized risk assessment, and informed decision-making in preventive care."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture
Sample Rejection Criteria:
  • Hemolyzed or contaminated sample
  • Insufficient sample volume
  • Improperly labeled or stored samples

Understanding Your Results

Results indicate the presence or absence of mutations in the XRCC3 gene linked to breast cancer susceptibility. Positive results suggest increased risk, while negative results indicate no detected pathogenic variants.
Positive: Pathogenic variant detected – increased breast cancer risk; consult healthcare provider for further management.
Negative: No pathogenic variants detected – standard risk; continue routine screenings.
Variant of uncertain significance (VUS): Further testing or family studies may be needed.
⚠️ When to Consult a Doctor:

If you have a family history of breast cancer, experience symptoms like breast lumps or changes, or receive a positive genetic test result, consult a healthcare provider promptly.

Limitations

  • ⚠May not detect all genetic variants or mutations
  • ⚠Results require interpretation by a genetic counselor or healthcare provider
  • ⚠Does not diagnose breast cancer but indicates susceptibility

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising, infection)
  • ●Potential psychological impact of results

Interfering Factors

  • ●Sample degradation
  • ●Contamination during collection or processing

Frequently Asked Questions

What is the XRCC3 Gene Breast Cancer Susceptibility NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the XRCC3 gene, which are associated with an increased risk of developing breast cancer.
Who should consider this test?
Individuals with a family history of breast cancer, those with symptoms, or those referred for genetic counseling due to high-risk factors.
How is the test performed?
A blood sample or extracted DNA is collected and analyzed using NGS technology to identify mutations in the XRCC3 gene.
What is the cost of the test?
The cost is INR 20,000, which includes testing, analysis, and a detailed report.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across many cities in India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the results mean?
Results indicate if pathogenic mutations in the XRCC3 gene are detected, which may increase breast cancer risk. Genetic counseling is recommended for interpretation.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw, but there may be psychological impacts based on results.
How accurate is the NGS genetic test?
NGS is highly accurate for detecting genetic mutations, but no test is 100% foolproof. Results should be interpreted by a professional.
Can this test diagnose breast cancer?
No, this test assesses genetic susceptibility to breast cancer but does not diagnose the disease itself.
What should I do if I have a positive result?
Consult a healthcare provider or genetic counselor to discuss risk management options, such as enhanced screening or preventive measures.
Is genetic counseling provided?
Yes, a genetic counseling session is recommended before and after testing to draw a family pedigree chart and discuss results.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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