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Activated Protein C-Resistance (APCR) Test

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Activated Protein C-Resistance (APCR) Test

Short Name: APCR Test

Also known as: APCR Test, Factor V Leiden Test

Activated Protein C-Resistance (APCR) Test test available at DNA Labs India for ₹5,200. Uses Electromechanical Clot Detection on Whole blood samples. Results in Sample collected by 11 AM Wednesday; report available next day.. Free home collection in 300+ cities across India.

Blood Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the APCR test is to detect genetic resistance to activated protein C, which can indicate an increased risk of blood clots. It helps in diagnosing thrombophilia, guiding treatment, and preventing complications in individuals with a personal or family history of thromboembolic disorders.

Test Code
60
Price
₹5,200
Sample Type
Whole blood
Result Time
Sample collected by 11 AM Wednesday; report available next day.
Fasting Required
Yes (8 hours)
Method
Electromechanical Clot Detection
Step 1

Sample Collection

Duly filled Coagulation Requisition Form (Form 15) is mandatory. Discontinue Heparin for 1 day and Oral Anticoagulants for 7 days prior with physician consent. Overnight fasting is preferred.

Method: Venipuncture

Step 2

Laboratory Analysis

Collect 3 mL whole blood in a Blue Top (Sodium Citrate) tube. Mix thoroughly by inversion.

Step 3

Report Delivery

Transport to lab within 4 hours. If delayed, prepare Platelet-Poor Plasma (PPP) within 1 hour: centrifuge at 3600 rpm for 15 min, transfer supernatant, centrifuge again, and freeze immediately. Ship frozen.

Timeline: Sample collected by 11 AM Wednesday; report available next day.

Patient Instructions

1
Before the Test:Fast overnight if preferred. Discontinue anticoagulants as advised. Complete Coagulation Requisition Form.
2
During the Test:A blood sample is drawn from a vein in your arm.
3
After the Test:Apply pressure to the puncture site. Resume normal activities. Monitor for any signs of clotting if at risk.

About This Test

Who Should Get This Test

The purpose of the APCR test is to detect genetic resistance to activated protein C, which can indicate an increased risk of blood clots. It helps in diagnosing thrombophilia, guiding treatment, and preventing complications in individuals with a personal or family history of thromboembolic disorders.

How to Prepare

  • Use Blue Top (Sodium Citrate) tube
  • Collect 3 mL whole blood
  • Mix by inversion 8-10 times
  • Process or transport promptly

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"APCR is a key genetic risk factor for thrombosis. Early detection via this test can guide preventive care and reduce complications like DVT or PE."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood
Sample Volume3 mL
ContainerBlue Top (Sodium Citrate) tube
Collection MethodVenipuncture

Sample Stability

Room Temperature4 hours
Refrigerator4 hours
Frozen2 weeks
Sample Rejection Criteria:
  • Improper sample volume
  • Hemolyzed or clotted sample
  • Incorrect tube type
  • Exceeding stability timeframes

Understanding Your Results

The APCR test result indicates whether there is resistance to activated protein C, often due to Factor V Leiden mutation. Interpretation should consider clinical history and other test results.
📊

APC Resistance Ratio ≥ 2.0

Normal response to APC; low risk of thrombophilia

📊

APC Resistance Ratio < 2.0

APC resistance detected; increased risk of blood clots

📊

Factor V Leiden Positive

Genetic mutation confirmed; requires further clinical evaluation

⚠️ When to Consult a Doctor:

If you have a family history of blood clots, personal history of DVT/PE, recurrent miscarriages, or symptoms like sudden leg swelling, shortness of breath, or chest pain, consult a healthcare provider or hematologist.

Limitations

  • ⚠Detects specific mutations only; may not identify all causes of APC resistance
  • ⚠Results should be interpreted in clinical context

Risks & Considerations

  • ●Minor bruising at puncture site
  • ●Rare infection or fainting

Interfering Factors

  • ●Heparin therapy (discontinue 1 day prior)
  • ●Oral anticoagulants (discontinue 7 days prior)
  • ●Improper sample handling or storage

Compare With Similar Tests

TestActivated Protein C-Resistance (APCR) TestFactor V Leiden Mutation TestProthrombin Time (PT)D-dimer Test
ComparisonActivated Protein C-Resistance (APCR) Test

Frequently Asked Questions

What is the APCR test?
The APCR test checks for resistance to activated protein C, a natural anticoagulant, often due to a genetic mutation like Factor V Leiden.
Why is the APCR test recommended?
It is recommended for individuals with a family history of blood clots, personal history of thrombosis, recurrent miscarriages, or prior to hormone therapy.
What are the symptoms of APCR?
APCR itself has no symptoms, but it increases the risk of blood clots, which may cause leg swelling, pain, shortness of breath, or chest pain.
How is the APCR test performed?
A blood sample is collected in a sodium citrate tube and tested for clotting response to activated protein C.
What is the cost of the APCR test in India?
At DNA Labs India, the cost is INR 5200, with free home collection available in many cities.
Do I need to fast before the APCR test?
Overnight fasting is preferred, but not mandatory. Follow instructions from your healthcare provider.
What medications affect the APCR test?
Heparin and oral anticoagulants can interfere; discontinue them 1 day and 7 days prior, respectively, with physician consent.
How long does it take to get APCR test results?
Results are typically available next day if the sample is received by 11 AM.
What does an abnormal APCR result mean?
An abnormal result indicates APC resistance, increasing the risk of blood clots. Consult a hematologist for further evaluation.
Is the APCR test covered by insurance?
Coverage varies; check with your insurance provider. Government schemes like PMJAY may not cover it.
Can the APCR test be done at home?
Yes, DNA Labs India offers free home collection for this test in numerous cities across India.
What are the risks of the APCR test?
Risks are minimal, similar to any blood draw: slight pain, bruising, or rare infection.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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