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Chimerism Split Cell Analysis - B Cell (CD19) Test

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Chimerism Split Cell Analysis - B Cell (CD19) Test

Short Name: CD19 Chimerism Test

Also known as: CD19 Chimerism Analysis, B Cell Chimerism Test, Split Cell Chimerism CD19

Chimerism Split Cell Analysis - B Cell (CD19) Test test available at DNA Labs India for ₹10,500. Uses PCR, STR / Fragment Analysis on Whole blood or bone marrow samples. Results in Report delivered within 7 working days after sample receipt.. Free home collection in 300+ cities across India.

Molecular DiagnosticAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To determine the presence and extent of chimerism in B cells, aiding in the monitoring of bone marrow transplant engraftment and immune reconstitution.

Test Code
291
Price
₹10,500
Sample Type
Whole blood or bone marrow
Result Time
Report delivered within 7 working days after sample receipt.
Fasting Required
No
Method
PCR, STR / Fragment Analysis
Step 1

Sample Collection

Indicate the date of bone marrow transplant and provide details of pre-transplant samples (patient and donor) registered under code N057.

Method: Blood draw or bone marrow aspiration

Step 2

Laboratory Analysis

A blood sample of 4 ml (minimum 2 ml) is drawn from a vein or bone marrow aspirated, collected in an EDTA tube.

Step 3

Report Delivery

Store the sample refrigerated; do not freeze. Ship to the lab promptly for analysis.

Timeline: Report delivered within 7 working days after sample receipt.

Patient Instructions

1
Before the Test:Ensure all clinical details, including transplant dates and prior samples, are provided.
2
During the Test:Sample collection via blood draw or bone marrow aspiration; procedure typically quick and minimally invasive.
3
After the Test:Results are available after 7 working days; follow up with your doctor for interpretation.

About This Test

Who Should Get This Test

To determine the presence and extent of chimerism in B cells, aiding in the monitoring of bone marrow transplant engraftment and immune reconstitution.

How to Prepare

  • Label the sample with patient details and transplant date
  • Use a Lavender Top (EDTA) tube
  • Ship refrigerated, avoid freezing
  • Include pre-transplant sample information if available

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This test is crucial for monitoring donor chimerism in B cells post-bone marrow transplant, helping assess engraftment and guide treatment adjustments."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood or bone marrow
Sample Volume4 ml (2 ml min.)
ContainerLavender Top (EDTA) tube
Collection MethodBlood draw or bone marrow aspiration

Sample Stability

Room Temperature: Not applicable
Refrigerator: 72 hours
Frozen: Not applicable
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Inadequate sample volume
  • Missing clinical information or sample mislabeling

Understanding Your Results

Results indicate the percentage of donor B cells in the sample, helping assess transplant success.
📊

Suggests good engraftment and immune reconstitution

Action: Continue standard post-transplant care

📊

Mixed chimerism; may indicate partial engraftment or relapse risk

Action: Consult physician for further evaluation and possible intervention

📊

Predominantly recipient cells; possible graft rejection or failure

Action: Urgent medical consultation for treatment adjustment

⚠️ When to Consult a Doctor:

Consult your doctor if chimerism levels change significantly, or if you experience symptoms like fever, infection, or transplant-related complications after testing.

Limitations

  • ⚠This test only analyzes B cell lineage; other cell lineages may require separate tests
  • ⚠Results are dependent on sample quality and timing post-transplant
  • ⚠Cannot distinguish between stable and unstable chimerism without longitudinal follow-up

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Rare risk of infection or bleeding from bone marrow aspiration

Interfering Factors

  • ●Hemolyzed or lipemic samples may affect results
  • ●Recent blood transfusions could interfere with chimerism assessment
  • ●Improper sample storage (e.g., freezing) may compromise DNA integrity

Compare With Similar Tests

TestChimerism Split Cell Analysis - B Cell (CD19) TestChimerism Analysis - T Cell (CD3)Chimerism Analysis - OverallBone Marrow AspirationHLA Typing
ComparisonChimerism Split Cell Analysis - B Cell (CD19) Test

Frequently Asked Questions

What is chimerism?
Chimerism is a condition where an individual has two or more genetically distinct cell populations, often occurring after bone marrow transplantation.
Why is the CD19 B Cell test specific?
It targets B cells to assess immune reconstitution separately, providing detailed insights into transplant engraftment.
How is the test performed?
A blood or bone marrow sample is collected in an EDTA tube and analyzed using PCR and STR/Fragment Analysis in the lab.
What does a high donor chimerism percentage indicate?
It typically indicates good engraftment of donor cells, suggesting transplant success.
Is the test painful?
The blood draw involves minimal discomfort; bone marrow aspiration may require local anesthesia but is generally well-tolerated.
How long does it take to get results?
Reports are delivered within 7 working days after sample collection.
Can this test be done at home?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What is the cost of the test?
The test costs INR 10500, which includes sample collection, analysis, and report delivery.
Who should order this test?
It is typically ordered by hematologists or oncologists for patients post-bone marrow transplant to monitor chimerism.
What if my results show mixed chimerism?
Mixed chimerism may require further evaluation; consult your doctor for potential interventions like medication adjustments.
Are there any risks associated with the test?
Risks are minimal, including bruising from blood draw; bone marrow aspiration carries slight risks of infection or bleeding.
How accurate is the test?
The test is highly accurate when performed with proper sample handling and validated laboratory methods.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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