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DNA Labs India

HLA Pre-Transplant Workup Sensitized Recipient Panel 4 Test

DNA Labs India | ISO 9001:2015 Certified

HLA Pre-Transplant Workup Sensitized Recipient Panel 4 Test

Short Name: HLA Sensitized Recipient Panel 4

Also known as: HLA Typing for Sensitized Recipients, Pre-Transplant Antibody Screening, HLA Compatibility Test

HLA Pre-Transplant Workup Sensitized Recipient Panel 4 Test test available at DNA Labs India for ₹19,071. Uses Complement Dependent Cytotoxicity with DTT treatment, Reverse SSOP - Luminex, Luminex X-Map technology, Flow cytometry, Sequence based Typing (SBT) on Whole blood from donor and recipient samples. Results in 10-12 days from sample collection. Free home collection in 300+ cities across India.

Pre-Transplant WorkupAdult🏠 Home Collection

🩺 Medically Reviewed By

Overview

To evaluate donor-recipient HLA compatibility at high resolution, screen for allo-immunization, and assess the level of sensitization to ensure successful transplantation.

Test Code
822
Price
₹19,071
Sample Type
Whole blood from donor and recipient
Result Time
10-12 days from sample collection
Fasting Required
No
Method
Complement Dependent Cytotoxicity with DTT treatment, Reverse SSOP - Luminex, Luminex X-Map technology, Flow cytometry, Sequence based Typing (SBT)
Step 1

Sample Collection

Obtain doctor's prescription on letterhead with photographs of recipient and donor, and signed consent form for HLA typing (Form 33).

Method: Venipuncture

Step 2

Laboratory Analysis

Collect blood samples from donor and recipient using specified tubes via venipuncture.

Step 3

Report Delivery

Ship samples at room temperature (18-22°C). Do not refrigerate or freeze.

Timeline: 10-12 days from sample collection

Patient Instructions

1
Before the Test:Ensure all pre-test requirements are met, including prescription and consent form. No fasting is required.
2
During the Test:Blood samples will be collected from donor and recipient at the lab or via home collection service.
3
After the Test:Wait for 10-12 days for results. Report will be delivered through online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

To evaluate donor-recipient HLA compatibility at high resolution, screen for allo-immunization, and assess the level of sensitization to ensure successful transplantation.

How to Prepare

  • Donor: Collect 12 mL whole blood in 2 Yellow Top (ACD) tubes
  • Recipient: Collect 4 mL whole blood in 1 Lavender Top (EDTA) tube
  • Also collect 4 mL whole blood in 1 Green Top (Sodium Heparin) tube
  • Maintain samples at room temperature (18-22°C) during shipment
  • Do not refrigerate or freeze samples

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This test is crucial for evaluating sensitization in transplant recipients to prevent rejection and ensure donor-recipient compatibility."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood from donor and recipient
Sample VolumeDonor: 12 mL ACD, 4 mL EDTA, 4 mL Heparin; Recipient: Similar volumes
ContainerYellow Top (ACD), Lavender Top (EDTA), Green Top (Sodium Heparin) tubes
Collection MethodVenipuncture

Sample Stability

Room Temperature24 hours
RefrigeratorNot applicable
FrozenNot applicable
Sample Rejection Criteria:
  • Insufficient sample volume
  • Use of improper sample containers
  • Missing doctor's prescription or consent form
  • Hemolyzed, clotted, or improperly labeled samples

Understanding Your Results

Results indicate the degree of HLA mismatch and sensitization level between donor and recipient. High sensitization may increase the risk of transplant rejection.
📊

Low sensitization and good HLA match

Lower risk of rejection; transplant may proceed with standard protocols.

📊

High sensitization or poor HLA match

Higher risk of rejection; desensitization therapies or alternative donor selection may be needed.

📊

Positive donor-specific antibodies

Indicates immune recognition of donor tissue; requires careful evaluation by transplant specialist.

⚠️ When to Consult a Doctor:

Consult your nephrologist or transplant specialist immediately after receiving test results to discuss transplant eligibility and potential rejection management strategies.

Limitations

  • Cannot detect all forms of sensitization
  • Results depend on sample quality and laboratory conditions
  • May require repeat testing in certain cases
  • Interpretation requires expert medical consultation

Risks & Considerations

  • Minor bruising or pain at the blood draw site
  • Rare risk of infection or fainting
  • No significant long-term risks

Interfering Factors

  • Hemolyzed or clotted blood samples
  • Improper sample storage or handling
  • Incorrect tube type used
  • Recent blood transfusions may affect antibody levels

Compare With Similar Tests

TestHLA Pre-Transplant Workup Sensitized Recipient Panel 4 TestHLA Typing for Kidney TransplantPanel Reactive Antibody (PRA) Test
ComparisonHLA Pre-Transplant Workup Sensitized Recipient Panel 4 Test

Frequently Asked Questions

What is the HLA Pre-Transplant Workup Sensitized Recipient Panel 4 Test?
It is a blood test that assesses donor-recipient compatibility and sensitization status before transplantation to prevent rejection.
Why is this test important before a transplant?
It helps identify sensitization risks, which can cause transplant rejection, and ensures proper HLA matching for a successful outcome.
Who needs this test?
Recipients with a history of blood transfusions, pregnancies, or previous transplants, or those undergoing pre-kidney transplant evaluation.
How is the test performed?
Blood samples from donor and recipient are analyzed using methods like Luminex and sequencing to detect HLA antibodies and typing.
What samples are required?
Donor: 12 mL in ACD tubes, plus 4 mL each in EDTA and Heparin tubes; Recipient: similar volumes as specified.
How long does it take to get results?
Results are typically available within 10-12 days from sample collection.
What does sensitization mean in transplantation?
Sensitization is when the recipient's immune system has antibodies against donor tissues, increasing rejection risk.
Can this test be done at home?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
Is fasting required for this test?
No, fasting is not required, but a doctor's prescription and consent form are mandatory.
What if the test shows high sensitization?
High sensitization may require desensitization treatments or careful donor selection; consult your transplant specialist.
How accurate is the test?
The test uses advanced, internationally validated methods to provide accurate and reliable results.
What is the cost of the test?
The cost at DNA Labs India is INR 19071.0, with free home collection included.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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