MDS Panel (Cytogenetics + FISH [del(5q), del(7q), del(20q)]) Test
Short Name: MDS Panel
Also known as: MDS Cytogenetics and FISH Panel, MDS Chromosome Analysis with FISH
MDS Panel (Cytogenetics + FISH [del(5q), del(7q), del(20q)]) Test test available at DNA Labs India for ₹12,750. Uses Cell Culture, FISH on Bone marrow / Peripheral blood samples. Results in Reports are typically available within 5-7 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of the MDS Panel is to aid in the diagnosis, prognosis, and management of Myelodysplastic Syndromes. By identifying specific chromosomal deletions, the test helps clinicians determine the risk category of MDS, which influences therapeutic choices such as lenalidomide for del(5q) or stem cell transplantation for high-risk cases. It also helps differentiate MDS from other causes of cytopenias and monitors disease progression or response to therapy.
- Test Code
- 6132
- CPT Code
- 88230, 88237, 88271, 88291
- ICD Code
- D46.9
- Price
- ₹12,750
- Sample Type
- Bone marrow / Peripheral blood
- Result Time
- Reports are typically available within 5-7 days after sample collection.
- Fasting Required
- No
- Method
- Cell Culture, FISH
Sample Collection
No special preparation required. Inform your doctor about any medications or recent transfusions.
Method: Venipuncture or bone marrow aspiration
Laboratory Analysis
Sample collection involves a standard blood draw or bone marrow aspiration. Mild discomfort may occur.
Report Delivery
No specific aftercare required. You can resume normal activities immediately.
Timeline: Reports are typically available within 5-7 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the MDS Panel is to aid in the diagnosis, prognosis, and management of Myelodysplastic Syndromes. By identifying specific chromosomal deletions, the test helps clinicians determine the risk category of MDS, which influences therapeutic choices such as lenalidomide for del(5q) or stem cell transplantation for high-risk cases. It also helps differentiate MDS from other causes of cytopenias and monitors disease progression or response to therapy.
How to Prepare
- Use Sodium Heparin Vacutainer (2 ml)
- Transport immediately at cool pack (2-8°C)
- Do not freeze the sample
- Label the sample with patient details and collection time
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"The MDS Panel is essential for risk stratification and guiding therapy in myelodysplastic syndromes. Early detection of del(5q), del(7q), and del(20q) can significantly impact management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed sample
- Incorrect anticoagulant (e.g., EDTA)
- Sample older than 72 hours
- Improper labeling or missing requisition form
Understanding Your Results
Associated with better prognosis, often responsive to lenalidomide
Associated with poor prognosis, higher risk of progression to AML
Variable prognosis, often seen in MDS and myeloproliferative disorders
No evidence of the tested abnormalities; other genetic tests may be needed
Consult your hematologist or oncologist if you have symptoms like persistent fatigue, unexplained bruising, recurrent infections, or if your blood counts are abnormal. The MDS Panel results should be discussed with your doctor to plan further management.
Limitations
- ⚠Cytogenetics may miss small deletions not visible on karyotype
- ⚠FISH only detects targeted abnormalities, not all possible MDS-related changes
- ⚠Bone marrow sample is preferred for higher sensitivity; peripheral blood may have lower yield
- ⚠Results should be interpreted in conjunction with clinical and morphological findings
Risks & Considerations
- ●Minimal risk of bleeding or infection at the collection site
- ●Bone marrow aspiration may cause temporary discomfort or soreness
- ●Rare risk of nerve damage (very low)
Interfering Factors
- ●Recent blood transfusion may dilute abnormal cells
- ●Insufficient metaphase cells for cytogenetic analysis
- ●Heparin contamination or improper sample handling
- ●Delayed transport leading to cell death
Compare With Similar Tests
| Test | MDS Panel (Cytogenetics + FISH [del(5q), del(7q), del(20q)]) | Bone Marrow Biopsy | Conventional Cytogenetics | FISH alone | Next-Generation Sequencing (NGS) |
|---|---|---|---|---|---|
| Comparison | MDS Panel (Cytogenetics + FISH [del(5q), del(7q), del(20q)]) | Provides morphological assessment of marrow cellularity and dysplasia, but does not detect chromosomal abnormalities. | Part of the MDS Panel, but alone may miss small deletions; FISH adds sensitivity. | Targets specific abnormalities but does not provide a full karyotype; combined with cytogenetics gives comprehensive information. | Detects gene mutations, but does not replace cytogenetics/FISH for chromosomal deletions. |
Frequently Asked Questions
What is the cost of the MDS Panel test at DNA Labs India?
What is the difference between cytogenetics and FISH?
Why are del(5q), del(7q), and del(20q) important in MDS?
What sample is required for the MDS Panel?
Do I need to fast before the test?
How long does it take to get the results?
Can the test be done without a doctor's prescription?
Is home sample collection available?
What does a positive result mean?
Are there any risks associated with the test?
Can this test be used for monitoring treatment response?
Is the test covered by insurance?
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