Mixing Studies - APTT Test
Short Name: APTT Mixing Test
Also known as: APTT Mixing Study, Clotting Time Mixing Test, Mixing Study for APTT
Mixing Studies - APTT Test test available at DNA Labs India for ₹4,500. Uses Photo-optical Clot Detection on Whole blood samples. Results in Reports are available next day after sample collection on Wednesday/Saturday.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Gottipati Vemkateswarlu
Consultant Hematologist · Reg: AMC4946
Last reviewed: September 7, 2026
Overview
The primary purpose of the Mixing Studies - APTT Test is to diagnose clotting disorders by assessing whether a prolonged APTT is due to a deficiency in clotting factors or the presence of inhibitors. It helps in guiding treatment decisions, such as factor replacement therapy or anticoagulant management, and is used to monitor the effectiveness of treatment for coagulation abnormalities.
- Test Code
- 1255
- Price
- ₹4,500
- Sample Type
- Whole blood
- Result Time
- Reports are available next day after sample collection on Wednesday/Saturday.
- Fasting Required
- Yes (8 hours)
- Method
- Photo-optical Clot Detection
Sample Collection
Overnight fasting is preferred. Discontinue Heparin for 1 day and Oral Anticoagulants for 7 days prior to sampling, with prior consent from the treating physician. Duly filled Coagulation Requisition Form (Form 15) is mandatory.
Method: Venipuncture
Laboratory Analysis
Blood is drawn from a vein in the arm using standard venipuncture technique into 2 Blue Top (Sodium Citrate) tubes. Tubes must be mixed thoroughly by inversion immediately after collection.
Report Delivery
Apply pressure to the puncture site to stop bleeding. Avoid strenuous activity for a short period. Ensure sample is transported to the lab within 4 hours or processed as per stability guidelines (prepare platelet-poor plasma if delayed).
Timeline: Reports are available next day after sample collection on Wednesday/Saturday.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Mixing Studies - APTT Test is to diagnose clotting disorders by assessing whether a prolonged APTT is due to a deficiency in clotting factors or the presence of inhibitors. It helps in guiding treatment decisions, such as factor replacement therapy or anticoagulant management, and is used to monitor the effectiveness of treatment for coagulation abnormalities.
How to Prepare
- Collect 6 mL whole blood in 2 Blue Top (Sodium Citrate) tubes
- Mix tubes thoroughly by inversion
- Transport to lab within 4 hours or prepare platelet-poor plasma (PPP) within 1 hour if delay occurs
- Freeze PPP immediately if not tested; ship frozen without thawing
- Include completed Coagulation Requisition Form (Form 15)
Doctor's Notes
Reviewed by Dr Gottipati Vemkateswarlu — MBBS, MD (Haematology) · Reg. No. AMC4946
"This test is essential for differentiating between clotting factor deficiencies and inhibitors, which is critical for targeted therapy in coagulation disorders."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Incorrect container type
- Delayed transport beyond stability limits
- Missing or incomplete Coagulation Requisition Form
- Improper sample volume
Understanding Your Results
APTT corrects to normal range after mixing
Suggests clotting factor deficiency, such as in hemophilia
APTT does not correct after mixing
Suggests presence of inhibitors, such as lupus anticoagulant or specific factor inhibitors
Partial correction
May indicate combined deficiency or weak inhibitor presence; further testing recommended
Consult your doctor if you experience symptoms of clotting disorders (e.g., excessive bleeding, bruising), have abnormal test results, or before discontinuing any medications that affect coagulation.
Limitations
- ⚠May not detect all types of inhibitors
- ⚠Results can be affected by improper sample handling or transport
- ⚠Interpretation requires clinical correlation and may need additional testing
Risks & Considerations
- ●Minor bruising or discomfort at the puncture site
- ●Rare risk of infection or fainting
- ●Minimal bleeding in individuals with clotting disorders
Interfering Factors
- ●Heparin therapy
- ●Oral anticoagulants (e.g., warfarin)
- ●Liver disease
- ●Disseminated intravascular coagulation (DIC)
- ●Other medications affecting coagulation
Compare With Similar Tests
| Test | Mixing Studies - APTT Test | Prothrombin Time (PT/INR) | Thrombin Time | Factor Assays | Fibrinogen Test |
|---|---|---|---|---|---|
| Comparison | Mixing Studies - APTT Test |
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